Induced pluripotent stem cell lines derived from human somatic cells

Induced pluripotent stem cell lines derived from human somatic cells

December 2007- The authors of this study proved that it was possible to return somatic cell nuclei to an undifferentiated state by introducing Oct4, Sox2, Nanog, and Lin28. These four factors were sufficient to induce pluripotency in human somatic cells. The normal karyotypes, expression of telomerase activity, expression of cell surface markers and genes characterized in human ES cells, and potential of iPS cells to develop into cells formed by any of the three germ layers proved their pluripotency and similarity to ES cells (Yu et al., 2007).